Category: Uncategorized

Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes

Nature Biotechnology, Published online: 18 January 2021; doi:10.1038/s41587-020-00795-2 Clonal subpopulations in human tumors are identified from single-cell RNA-seq data. Source: Nature Biotecnology

Assessing single-cell transcriptomic variability through density-preserving data visualization

Nature Biotechnology, Published online: 18 January 2021; doi:10.1038/s41587-020-00801-7 den-SNE and densMAP enhance single-cell transcriptomic data visualization by incorporating density information. Source: Nature Biotecnology

inStrain profiles population microdiversity from metagenomic data and sensitively detects shared microbial strains

Nature Biotechnology, Published online: 18 January 2021; doi:10.1038/s41587-020-00797-0 A metagenome analysis tool identifies microbial strains within and between populations. Source: Nature Biotecnology

Research priorities for COVID-19 sensor technology

Nature Biotechnology, Published online: 18 January 2021; doi:10.1038/s41587-021-00816-8 Research priorities for COVID-19 sensor technology Source: Nature Biotecnology

Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease

Nature Medicine, Published online: 18 January 2021; doi:10.1038/s41591-020-01198-1 Reduced meningeal lymphatic flow detected in patients with idiopathic Parkinson’s disease compared to patients with atypical Parkinsonian disorders and cognitively normal controls. Source: Nature Medicine

Durvalumab compared to maintenance chemotherapy in metastatic breast cancer: the randomized phase II SAFIR02-BREAST IMMUNO trial

Nature Medicine, Published online: 18 January 2021; doi:10.1038/s41591-020-01189-2 Exploratory analyses from the phase 2 randomized SAFIR02-IMMUNO trial identify biomarkers associated with improved outcomes to durvalumab as compared to maintenance chemotherapy in patients with triple-negative breast cancer. Source: Nature Medicine

High-frequency neuromodulation improves obsessive–compulsive behavior

Nature Medicine, Published online: 18 January 2021; doi:10.1038/s41591-020-01173-w Selective and personalized neuromodulation of orbitofrontal beta–gamma rhythms in humans, achieved with an alternating current, robustly attenuates obsessive–compulsive behavior for 3 months. Source: Nature Medicine

The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer

Nature Medicine, Published online: 18 January 2021; doi:10.1038/s41591-020-01168-7 Functional interplay of sex hormones in estrogen receptor–positive breast cancer unveils the therapeutic potential of androgen receptor agonists. Source: Nature Medicine

State-dependent responses to intracranial brain stimulation in a patient with depression

Nature Medicine, Published online: 18 January 2021; doi:10.1038/s41591-020-01175-8 Acute mapping of responses to focal electrical neuromodulation in a patient with treatment-resistant depression reveals distinct mood and symptom changes that are highly context dependent. Source: Nature Medicine

Così gli scienziati hanno fotografato il caos ottico

Grazie a una videocamera e una tecnica di fotografia ultraveloci, i ricercatori californiani sono riusciti a studiare, controllare e visualizzare in tempo reale il caos ottico Source: La Repubblica scienze