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Dai topi un nuovo modello per studiare la vista dell'uomo

Una ricerca dimostra che i ratti riconoscono gli oggetti in modo simile all’uomo, aprendo la strada a possibili applicazioni sperimentali  Source: La Repubblica scienze

Università di Padova – Tumori: arriva il killer che uccide solo le cellule malate

Comunicato stampa – Un gruppo di ricercatori pone le basi per una nuova terapia anti-tumorale… Source: Le Scienze Medicina

Usa, via libera al test del Dna 'fai da te' su 10 malattie

Luce verde alla commercializzazione dei test genetici dell’azienda californiana. Basta un campione di saliva per conoscere la propria predisposizione a diverse… Source: La Repubblica scienze

Genome-wide target specificities of CRISPR RNA-guided programmable deaminases

Nature Biotechnology. doi:10.1038/nbt.3852 Authors: Daesik Kim, Kayeong Lim, Sang-Tae Kim, Sun-heui Yoon, Kyoungmi Kim, Seuk-Min Ryu & Jin-Soo Kim Cas9-linked deaminases, also called base editors, enable targeted mutation of single nucleotides in eukaryotic genomes. However, their off-target activity is largely unknown. Here we modify digested-genome sequencing (Digenome-seq) to assess the specificity of a programmable deaminase…
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A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability

Nature Medicine. doi:10.1038/nm.4323 Authors: Anne-Pierre Morel, Christophe Ginestier, Roxane M Pommier, Olivier Cabaud, Emmanuelle Ruiz, Julien Wicinski, Mojgan Devouassoux-Shisheboran, Valérie Combaret, Pascal Finetti, Christelle Chassot, Christiane Pinatel, Frédérique Fauvet, Pierre Saintigny, Emilie Thomas, Caroline Moyret-Lalle, Joël Lachuer, Emmanuelle Despras, Jean-Luc Jauffret, François Bertucci, Jérôme Guitton, Anne Wierinckx, Qing Wang, Nina Radosevic-Robin, Frédérique Penault-Llorca, David G…
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Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

Nature Medicine. doi:10.1038/nm.4314 Authors: Donnele Daley, Vishnu R Mani, Navyatha Mohan, Neha Akkad, Atsuo Ochi, Daniel W Heindel, Ki Buom Lee, Constantinos P Zambirinis, Gautam SD Balasubramania Pandian, Shivraj Savadkar, Alejandro Torres-Hernandez, Shruti Nayak, Ding Wang, Mautin Hundeyin, Brian Diskin, Berk Aykut, Gregor Werba, Rocky M Barilla, Robert Rodriguez, Steven Chang, Lawrence Gardner, Lara K…
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A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

Nature Medicine. doi:10.1038/nm.4322 Authors: Chao Shan, Antonio E Muruato, Bruno T D Nunes, Huanle Luo, Xuping Xie, Daniele B A Medeiros, Maki Wakamiya, Robert B Tesh, Alan D Barrett, Tian Wang, Scott C Weaver, Pedro F C Vasconcelos, Shannan L Rossi & Pei-Yong Shi Zika virus (ZIKV) infection of pregnant women can cause a wide…
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A heart–brain–kidney network controls adaptation to cardiac stress through tissue macrophage activation

Nature Medicine. doi:10.1038/nm.4326 Authors: Katsuhito Fujiu, Munehiko Shibata, Yukiteru Nakayama, Fusa Ogata, Sahohime Matsumoto, Koji Noshita, Shingo Iwami, Susumu Nakae, Issei Komuro, Ryozo Nagai & Ichiro Manabe Source: Nature Medicine

Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Nature Medicine. doi:10.1038/nm.4305 Authors: Luigina Romani, Vasilis Oikonomou, Silvia Moretti, Rossana G Iannitti, Maria Cristina D’Adamo, Valeria R Villella, Marilena Pariano, Luigi Sforna, Monica Borghi, Marina M Bellet, Francesca Fallarino, Maria Teresa Pallotta, Giuseppe Servillo, Eleonora Ferrari, Paolo Puccetti, Guido Kroemer, Mauro Pessia, Luigi Maiuri, Allan L Goldstein & Enrico Garaci Source: Nature Medicine

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

Nature Biotechnology. doi:10.1038/nbt.3835 Authors: Pia Rivetti di Val Cervo, Roman A Romanov, Giada Spigolon, Débora Masini, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Michael Feyder, Christian Pifl, Yi-Han Ng, Sara Padrell Sánchez, Sten Linnarsson, Marius Wernig, Tibor Harkany, Gilberto Fisone & Ernest Arenas Source: Nature Biotecnology