Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

Nature Biotechnology.
doi:10.1038/nbt.3948

Authors: Naoki Iwamoto, David C D Butler, Nenad Svrzikapa, Susovan Mohapatra, Ivan Zlatev, Dinah W Y Sah, Stephany M Standley, Genliang Lu, Luciano H Apponi, Maria Frank-Kamenetsky, Jason Jingxin Zhang, Chandra Vargeese & Gregory L Verdine

Source: Nature Biotecnology