Nature Medicine.
doi:10.1038/nm.4330
Authors: Alice D Lam, Gina Deck, Alica Goldman, Emad N Eskandar, Jeffrey Noebels & Andrew J Cole
We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer’s disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.
Source: Nature Medicine